Ophthalmic Drug Products – Recent Webinar and Velesco’s Capabilities

The Velesco team recently attended an ophthalmic drug product webinar.  The training titled ‘Ophthalmic Products – Quality and Performance Tests’ was presented by Margareth R.C. Marques, M.Sc., PhD., USP Senior Scientific Liason.  This webinar was of interest to us due to our extensive experience with ophthalmic drug products which includes analytical method development, small scale...

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Velesco’s Non-Clinical Formulation Philosophy – Part 2

Apologies for the long delay between part 1 and 2 of this topic.  I’m sure that everyone was waiting with bated breath! Last time, I wrote about the importance of order of addition to the successful solubilization of drugs.  This time, I will touch on energy and some notes that early drug developers need to know about solid state chemistry and solubility. There are many great resources that...

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Peeps® and Solubility – Are You Fascinated By Both Topics? See How They Are Related.

Dear readers, are you fascinated by Peeps?  Join the club! I just Googled some solubility terms in preparation of writing another blog post about solubility and what comes up second on Google’s list?  A website all about Peeps, including experiments trying to dissolve them! http://www.peepresearch.org/solubility.html Dig further on that website to unveil much more Peep excitement, you will...

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Formulating an Oral Suspension (part 2)

In part 1 of this article I described the need to ensure the delivery of a uniform dose of a suspension, how this can be achieved and the challenges that can be encountered.  In part 2 I’d like to discuss preserving against microbial growth, taste & “mouthfeel” and manufacturability.  Suppressing microbial growth Aqueous solutions containing viscosity modifying polymers and other...

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Formulating an Oral Suspension (part 1)

  Frequently we at Velesco are approached with a request to formulate a suspension of a new compound for use in a clinical study.  Often this request contains the helpful information “we mixed some drug with some 2% methylcellulose solution and dosed it to the rats without issues so this shouldn’t be a big job, right?” Well maybe yes but probably no is the answer to that. Formulating...

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Practical Aspects of Solubility Determination Article – Some Thoughts

I’ve just finished reading a nice review article in American Pharmaceutical Review discussing practical aspects of solubility determination.  I am an extremely practical scientist and am drawn to articles with the word “practical” in the title! This article touches on a few nice discussion points that affect our early small molecule formulation work greatly.  When we develop a...

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